Research

1. Viral Assembly & Antiviral Strategies & Advanced Biotechnology

We investigate the critical stage of the viral replication cycle: how hundreds of structural proteins interact with viral RNA to assemble into new infectious particles. By deciphering the structural and functional mechanics of these interactions, we aim to design targeted inhibitors that block viral assembly and halt infection. We also focus on the production of advanced peptide-based therapeutics.

Retroviruses: We study RNA-to-DNA reverse-transcribing viruses, with a primary focus on HIV.

Flaviviruses: We research severe global and regional pathogens, including the Dengue, Zika, and Tick-borne encephalitis (TBE) viruses.

Next-Generation Peptides: Production of advanced peptide-based drugs and therapeutics containing non-canonical amino acids by Genetic code expansion using in vitro (Cell-Free Protein Synthesis - CFPS) and in vivo methods.

Key Techniques: To study these complex processes, we routinely employ a broad spectrum of molecular and cellular methods, including DNA/RNA isolation, molecular cloning, mutagenesis, tissue culture techniques, qPCR, Western Blotting (WB), Fast Protein Liquid Chromatography (FPLC), FACS, ELISA, CRISPR techniques and more.

Explore our publications and learn more about our research.

Highlighted

Unveiling the DHX15–G-patch interplay in retroviral RNA packaging

Alžběta Dostálková, Ivana Křížová, Petra Junková, Jana Racková, Marina Kapisheva, …, Larisa Šinkovec, Kateřina Večerková, Lucie Bednárová, Tomáš Ruml, Michaela Rumlová

Proceedings of the National Academy of Sciences  ·  25 Sep 2024  ·  doi:10.1073/PNAS.2407990121

We explored how a simple retrovirus, Mason-Pfizer monkey virus (M-PMV) to facilitate its replication process, utilizes DHX15, a cellular RNA helicase, typically engaged in RNA processing.

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2026

Retroviruses use different IP6 binding mechanisms to alter the properties of their capsids

J. Ole Klarhof, Donna L. Mallery, James C. V. Stacey, Davide Torre, Michaela Rumlova, Tomas Ruml, John A. G. Briggs, Leo C. James

Nature Communications  ·  21 Aug 2026  ·  doi:10.1038/s41467-026-76510-7

N-Alkylated Monoterpene Indole Alkaloid Derivatives as Chemotherapy Adjuvants That Overcome P-glycoprotein-Mediated Multidrug Resistance in Cancer Cells, Spheroids and Patient-Derived Colorectal Cancer Organoids

Tomáš Nejedlý, Ondřej Strnad, Jan Ulrych, Václav Hanžl, Ivana Křížová, …, David Paulino Cardoso, Silva F Mulhovo, Markéta Častorálová, Maria-José U Ferreira, Jitka Viktorová

Drug Design, Development and Therapy  ·  01 Aug 2026  ·  doi:10.2147/DDDT.S615974

Co-release of tick-borne encephalitis virus RNA and structural proteins via virus-like particles and extracellular vesicles

Ivana Křížová, Anna Klimešová, Alžběta Dostálková, Jana Racková, Jiřina Kaufmanová, …, Ivana Matošević, Zdeněk Franta, Hana Tykalová, Libor Grubhoffer, Michaela Rumlová

Journal of General Virology  ·  29 Apr 2026  ·  doi:10.1099/jgv.0.002258

Protease‐mediated maturation of M‐ PMV reverse transcriptase into a functional heterodimer

Marina Kapisheva, Petra Junková, Ondřej Vaněk, Zuzana Jalovcová, Ivana Křížová, Alžběta Dostálková, Michaela Rumlová

Protein Science  ·  20 Jan 2026  ·  doi:10.1002/pro.70469

2025

Allosteric Inhibitors of SARS‐CoV‐2 RNA‐Dependent RNA Polymerase Based on N , N′ ‐Diphenylurea

Artem Chayka, Matěj Danda, Alžběta Dostálková, Vojtěch Spiwok, Lamija Zijadic, …, Michala Zgarbová, Jan Weber, Tomáš Ruml, Michaela Rumlová, Zlatko Janeba

ChemMedChem  ·  22 Nov 2025  ·  doi:10.1002/cmdc.202500644

Bridging predictions with experimental reality: In vitro evaluation of phenolic natural products as SARS-CoV-2 exoribonuclease inhibitors

Matěj Danda, Barbora Chvátalová, Daniela Nečasová, Ivana Křížová, Tomáš Ruml, Michaela Rumlová

Biomedicine & Pharmacotherapy  ·  01 Nov 2025  ·  doi:10.1016/j.biopha.2025.118588

Modulating the anti-cancer photodynamic efficiency of molybdenum-iodide nanoclusters via ligand design

Tomáš Přibyl, Karel Škoch, Dmytro Bavol, Ivana Křížová, Jaroslav Zelenka, Tomáš Ruml, Kamil Lang, Kaplan Kirakci

Journal of Materials Chemistry B  ·  01 Jan 2025  ·  doi:10.1039/d5tb00401b

2024

Developing Allosteric Inhibitors of SARS‐CoV‐2 RNA‐Dependent RNA Polymerase

Artem Chayka, Matěj Danda, Alžběta Dostálková, Vojtěch Spiwok, Anna Klimešová, …, Michala Zgarbová, Jan Weber, Tomáš Ruml, Michaela Rumlová, Zlatko Janeba

ChemMedChem  ·  03 Oct 2024  ·  doi:10.1002/CMDC.202400367

Unveiling the DHX15–G-patch interplay in retroviral RNA packaging

Alžběta Dostálková, Ivana Křížová, Petra Junková, Jana Racková, Marina Kapisheva, …, Larisa Šinkovec, Kateřina Večerková, Lucie Bednárová, Tomáš Ruml, Michaela Rumlová

Proceedings of the National Academy of Sciences  ·  25 Sep 2024  ·  doi:10.1073/pnas.2407990121

Unveiling the DHX15–G-patch interplay in retroviral RNA packaging

Alžběta Dostálková, Ivana Křížová, Petra Junková, Jana Racková, Marina Kapisheva, …, Larisa Šinkovec, Kateřina Večerková, Lucie Bednárová, Tomáš Ruml, Michaela Rumlová

Proceedings of the National Academy of Sciences  ·  25 Sep 2024  ·  doi:10.1073/PNAS.2407990121

We explored how a simple retrovirus, Mason-Pfizer monkey virus (M-PMV) to facilitate its replication process, utilizes DHX15, a cellular RNA helicase, typically engaged in RNA processing.

Website

Biochemical characterization of naturally occurring mutations in SARS ‐ CoV ‐2 RNA ‐dependent RNA polymerase

Matěj Danda, Anna Klimešová, Klára Kušková, Alžběta Dostálková, Aneta Pagáčová, Jan Prchal, Marina Kapisheva, Tomáš Ruml, Michaela Rumlová

Protein Science  ·  15 Aug 2024  ·  doi:10.1002/pro.5103

Chlorin spiro-Tröger's base as a prospective photosensitizer for photodynamic therapy of cancer

Tereza Navrátilová, Denisa Pineckerová, Ameneh Tatar, Ivana Křížová, Martin Havlík, …, Jan Hajduch, Jaroslav Zelenka, Pavel Anzenbacher, Jr., Bohumil Dolenský

Journal of Photochemistry and Photobiology A: Chemistry  ·  01 Aug 2024  ·  doi:10.1016/j.jphotochem.2024.115618

PLGA-based nanocarriers for combined delivery of colchicine and purpurin 18 in cancer therapy: Multimodal approach employing cancer cell spheroids

Alma Lucia Villela Zumaya, Vladimíra Svobodová Pavlíčková, Silvie Rimpelová, Markéta Štějdířová, Michal Fulem, Ivana Křížová, Pavel Ulbrich, Pavel Řezanka, Fatima Hassouna

International Journal of Pharmaceutics  ·  01 May 2024  ·  doi:10.1016/j.ijpharm.2024.124170

Prevalence of SARS-CoV-2 variants in Prague wastewater determined by nanopore-based sequencing

Alžběta Dostálková, Kamila Zdeňková, Jana Bartáčková, Eliška Čermáková, Marina Kapisheva, …, Oldřich Bartoš, Jiří Dresler, Kateřina Demnerová, Michaela Rumlová, Jan Bartáček

Chemosphere  ·  01 Mar 2024  ·  doi:10.1016/j.chemosphere.2024.141162

Biochemical characterization of naturally occurring mutations in SARS-CoV-2 RNA-dependent RNA polymerase

Matěj Danda, Anna Klimešová, Klára Kušková, Alžběta Dostálková, Aneta Pagáčová, Jan Prchal, Marina Kapisheva, Tomáš Ruml, Michaela Rumlová

openRxiv  ·  26 Feb 2024  ·  doi:10.1101/2024.02.24.581855

PEGylated Molybdenum–Iodine Nanocluster as a Promising Radiodynamic Agent against Prostatic Adenocarcinoma

Tomáš Přibyl, Michaela Rumlová, Romana Mikyšková, Milan Reiniš, Antonín Kaňa, Karel Škoch, Jaroslav Zelenka, Kaplan Kirakci, Tomáš Ruml, Kamil Lang

Inorganic Chemistry  ·  16 Feb 2024  ·  doi:10.1021/ACS.INORGCHEM.4C00084

2023

Monitoring of monkeypox viral DNA in Prague wastewater

Jana Bartáčková, Vojtěch Kouba, Alžběta Dostálková, Eliška Čermáková, Marco A. Lopez Marin, …, Kateřina Demnerová, Michaela Rumlová, Petr Sýkora, Jan Bartáček, Kamila Zdeňková

Science of The Total Environment  ·  01 Dec 2023  ·  doi:10.1016/J.SCITOTENV.2023.166110

Alcohol-Free Beer Produced Using Maltose-Negative Wine Yeast Saccharomyces cerevisiae with Probiotic Potential

Emre İlpars, Štěpánka Titlová, Katarína Hanzalíková, Ivana Křížová, Tomáš Brányik

Fermentation  ·  31 Aug 2023  ·  doi:10.3390/fermentation9090805

National Institute of Virology and Bacteriology – A Reaction to Threats of Future Pandemics

Michaela Rumlová, Tomáš Ruml

Chemické listy  ·  15 Jul 2023  ·  doi:10.54779/CHL20230393

Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors

Jan Skácel, Stefan Djukic, Ondřej Baszczyňski, Filip Kalčic, Tadeáš Bílek, …, Jan Snášel, Iva Pichová, Pavlína Řezáčová, Helena Mertlíková-Kaiserová, Zlatko Janeba

Journal of Medicinal Chemistry  ·  03 May 2023  ·  doi:10.1021/ACS.JMEDCHEM.2C02097

Monitoring COVID-19 spread in selected Prague's schools based on the presence of SARS-CoV-2 RNA in wastewater

Marco A. Lopez Marin, K. Zdenkova, J. Bartackova, E. Cermakova, A. Dostalkova, …, L. Vavruskova, Z. Novakova, P. Sykora, M. Rumlova, J. Bartacek

Science of The Total Environment  ·  01 May 2023  ·  doi:10.1016/j.scitotenv.2023.161935

Radiosensitizing molybdenum iodide nanoclusters conjugated with a biocompatible N -(2-hydroxypropyl)methacrylamide copolymer: a step towards radiodynamic therapy

Kaplan Kirakci, Robert Pola, Marina Rodrigues Tavares, Michal Pechar, Tomáš Přibyl, Ivana Křížová, Jaroslav Zelenka, Tomáš Ruml, Tomáš Etrych, Kamil Lang

Materials Advances  ·  01 Jan 2023  ·  doi:10.1039/d3ma00577a

2022

Tick-borne encephalitis virus capsid protein induces translational shutoff as revealed by its structural–biological analysis

Martin Selinger, Radim Novotný, Jakub Sýs, Justin A. Roby, Hana Tykalová, …, Libor Grubhoffer, Jade K. Forwood, Richard Hrabal, Michaela Rumlová, Ján Štěrba

Journal of Biological Chemistry  ·  01 Nov 2022  ·  doi:10.1016/J.JBC.2022.102585

Fully Programmable Collective Behavior of Light‐Powered Chemical Microrobotics: pH‐Dependent Motion Behavior Switch and Controlled Cancer Cell Destruction

Lukas Dekanovsky, Yulong Ying, Jaroslav Zelenka, Jan Plutnar, Seyyed Mohsen Beladi‐Mousavi, Ivana Křížová, Filip Novotný, Tomáš Ruml, Martin Pumera

Advanced Functional Materials  ·  13 Jul 2022  ·  doi:10.1002/adfm.202205062

Monitoring COVID-19 spread in Prague local neighborhoods based on the presence of SARS-CoV-2 RNA in wastewater collected throughout the sewer network

Kamila Zdenkova, Jana Bartackova, Eliska Cermakova, Katerina Demnerova, Alzbeta Dostalkova, …, Iva Swierczkova, Petr Sykora, Dana Vejmelkova, Jiri Wanner, Jan Bartacek

Water Research  ·  01 Jun 2022  ·  doi:10.1016/j.watres.2022.118343

Monitoring COVID-19 spread in Prague local neighborhoods based on the presence of SARS-CoV-2 RNA in wastewater collected throughout the sewer network

Kamila Zdenkova, Jana Bartackova, Eliska Cermakova, Katerina Demnerova, Alzbeta Dostalkova, …, Iva Swierczkova, Petr Sykora, Dana Vejmelkova, Jiri Wanner, Jan Bartacek

Water Research  ·  01 Jun 2022  ·  doi:10.1016/J.WATRES.2022.118343

Correction: Křížová et al. Fullerene Derivatives Prevent Packaging of Viral Genomic RNA into HIV-1 Particles by Binding Nucleocapsid Protein. Viruses 2021, 13, 2451

Ivana Křížová, Alžběta Dostálková, Edison Castro, Jan Prchal, Romana Hadravová, …, Richard Hrabal, Tomáš Ruml, Manuel Llano, Luis Echegoyen, Michaela Rumlová

Viruses  ·  30 May 2022  ·  doi:10.3390/v14061187

Correction: Křížová et al. Fullerene Derivatives Prevent Packaging of Viral Genomic RNA into HIV-1 Particles by Binding Nucleocapsid Protein. Viruses 2021, 13, 2451

Ivana Křížová, Alžběta Dostálková, Edison Castro, Jan Prchal, Romana Hadravová, …, Richard Hrabal, Tomáš Ruml, Manuel Llano, Luis Echegoyen, Michaela Rumlová

Viruses  ·  30 May 2022  ·  doi:10.3390/V14061187

Alteration in DNA-binding affinity of Wilms tumor 1 protein due to WT1 genetic variants associated with steroid - resistant nephrotic syndrome in children

Martin Bezdicka, Filip Kaufman, Ivana Krizova, Alzbeta Dostalkova, Michaela Rumlova, Tomas Seeman, Karel Vondrak, Filip Fencl, Jakub Zieg, Ondrej Soucek

Scientific Reports  ·  24 May 2022  ·  doi:10.1038/s41598-022-12760-x

Alteration in DNA-binding affinity of Wilms tumor 1 protein due to WT1 genetic variants associated with steroid - resistant nephrotic syndrome in children

Martin Bezdicka, Filip Kaufman, Ivana Krizova, Alzbeta Dostalkova, Michaela Rumlova, Tomas Seeman, Karel Vondrak, Filip Fencl, Jakub Zieg, Ondrej Soucek

Scientific Reports  ·  24 May 2022  ·  doi:10.1038/S41598-022-12760-X

Cobalt Bis-Dicarbollide Enhances Antibiotics Action towards Staphylococcus epidermidis Planktonic Growth Due to Cell Envelopes Disruption

Eva Vaňková, Kristýna Lokočová, Petra Kašparová, Romana Hadravová, Ivana Křížová, Olga Maťátková, Jan Masák, Václav Šícha

Pharmaceuticals  ·  26 Apr 2022  ·  doi:10.3390/ph15050534

A Cell Membrane Targeting Molybdenum-Iodine Nanocluster: Rational Ligand Design toward Enhanced Photodynamic Activity

Kaplan Kirakci, Michaela Kubáňová, Tomáš Přibyl, Michaela Rumlová, Jaroslav Zelenka, Tomáš Ruml, Kamil Lang

Inorganic Chemistry  ·  16 Mar 2022  ·  doi:10.1021/ACS.INORGCHEM.2C00040

Integrative RNA profiling of TBEV-infected neurons and astrocytes reveals potential pathogenic effectors

Martin Selinger, Pavlína Věchtová, Hana Tykalová, Petra Ošlejšková, Michaela Rumlová, Ján Štěrba, Libor Grubhoffer

Computational and Structural Biotechnology Journal  ·  01 Jan 2022  ·  doi:10.1016/J.CSBJ.2022.05.052

Avenue to X-ray-induced photodynamic therapy of prostatic carcinoma with octahedral molybdenum cluster nanoparticles

Martina Koncošová, Michaela Rumlová, Romana Mikyšková, Milan Reiniš, Jaroslav Zelenka, Tomáš Ruml, Kaplan Kirakci, Kamil Lang

Journal of Materials Chemistry B  ·  01 Jan 2022  ·  doi:10.1039/D2TB00141A

2021

Polymeric Membranes Containing Iodine-Loaded UiO-66 Nanoparticles as Water-Responsive Antibacterial and Antiviral Surfaces

Kaplan Kirakci, Daniel Bůžek, Petra Peer, Vojtěch Liška, Jiří Mosinger, Ivana Křížová, Matouš Kloda, Soňa Ondrušová, Kamil Lang, Jan Demel

ACS Applied Nano Materials  ·  24 Dec 2021  ·  doi:10.1021/acsanm.1c03832

Heterocyclic Cathinones as Inhibitors of Kynurenine Aminotransferase II—Design, Synthesis, and Evaluation

Michal Maryška, Lucie Svobodová, Wim Dehaen, Martina Hrabinová, Michaela Rumlová, Ondřej Soukup, Martin Kuchař

Pharmaceuticals  ·  10 Dec 2021  ·  doi:10.3390/PH14121291

Fullerene Derivatives Prevent Packaging of Viral Genomic RNA into HIV-1 Particles by Binding Nucleocapsid Protein

Ivana Křížová, Alžběta Dostálková, Edison Castro, Jan Prchal, Romana Hadravová, …, Richard Hrabal, Tomáš Ruml, Manuel Llano, Luis Echegoyen, Michaela Rumlová

Viruses  ·  06 Dec 2021  ·  doi:10.3390/v13122451

Fullerene Derivatives Prevent Packaging of Viral Genomic RNA into HIV-1 Particles by Binding Nucleocapsid Protein

Ivana Křížová, Alžběta Dostálková, Edison Castro, Jan Prchal, Romana Hadravová, …, Richard Hrabal, Tomáš Ruml, Manuel Llano, Luis Echegoyen, Michaela Rumlová

Viruses  ·  06 Dec 2021  ·  doi:10.3390/V13122451

Inhibition of Mitochondrial Metabolism Leads to Selective Eradication of Cells Adapted to Acidic Microenvironment

Martina Koncošová, Nikola Vrzáčková, Ivana Křížová, Petra Tomášová, Silvie Rimpelová, Aleš Dvořák, Libor Vítek, Michaela Rumlová, Tomáš Ruml, Jaroslav Zelenka

International Journal of Molecular Sciences  ·  06 Oct 2021  ·  doi:10.3390/ijms221910790

Inhibition of Mitochondrial Metabolism Leads to Selective Eradication of Cells Adapted to Acidic Microenvironment

Martina Koncošová, Nikola Vrzáčková, Ivana Křížová, Petra Tomášová, Silvie Rimpelová, Aleš Dvořák, Libor Vítek, Michaela Rumlová, Tomáš Ruml, Jaroslav Zelenka

International Journal of Molecular Sciences  ·  06 Oct 2021  ·  doi:10.3390/IJMS221910790

Influence of Cultivation Conditions on the Sioxanthin Content and Antioxidative Protection Effect of a Crude Extract from the Vegetative Mycelium of Salinispora tropica

Zuzana Jezkova, Vera Schulzova, Ivana Krizova, Marcel Karabin, Tomas Branyik

Marine Drugs  ·  08 Sep 2021  ·  doi:10.3390/md19090509

Betulinic Acid Decorated with Polar Groups and Blue Emitting BODIPY Dye: Synthesis, Cytotoxicity, Cell-Cycle Analysis and Anti-HIV Profiling

David Kodr, Jarmila Stanková, Michaela Rumlová, Petr Džubák, Jiří Řehulka, …, Ivana Křížová, Soňa Gurská, Marián Hajdúch, Pavel B. Drašar, Michal Jurášek

Biomedicines  ·  28 Aug 2021  ·  doi:10.3390/biomedicines9091104

Betulinic Acid Decorated with Polar Groups and Blue Emitting BODIPY Dye: Synthesis, Cytotoxicity, Cell-Cycle Analysis and Anti-HIV Profiling

David Kodr, Jarmila Stanková, Michaela Rumlová, Petr Džubák, Jiří Řehulka, …, Ivana Křížová, Soňa Gurská, Marián Hajdúch, Pavel B. Drašar, Michal Jurášek

Biomedicines  ·  28 Aug 2021  ·  doi:10.3390/BIOMEDICINES9091104

Monitoring COVID-19 spread in Prague local neighborhoods based on the presence of SARS-CoV-2 RNA in wastewater collected throughout the sewer network

Kamila Zdenkova, Jana Bartackova, Eliska Cermakova, Katerina Demnerova, Alzbeta Dostalkova, …, Iva Swierczkova, Petr Sykora, Dana Vejmelkova, Jiri Wanner, Jan Bartacek

openRxiv  ·  31 Jul 2021  ·  doi:10.1101/2021.07.28.21261272

Effect of Small Polyanions on In Vitro Assembly of Selected Members of Alpha-, Beta- and Gammaretroviruses

Alžběta Dostálková, Barbora Vokatá, Filip Kaufman, Pavel Ulbrich, Tomáš Ruml, Michaela Rumlová

Viruses  ·  18 Jan 2021  ·  doi:10.3390/v13010129

Effect of Small Polyanions on In Vitro Assembly of Selected Members of Alpha-, Beta- and Gammaretroviruses

Alžběta Dostálková, Barbora Vokatá, Filip Kaufman, Pavel Ulbrich, Tomáš Ruml, Michaela Rumlová

Viruses  ·  18 Jan 2021  ·  doi:10.3390/V13010129

2020

Characterization of AMBN I and II Isoforms and Study of Their Ca2+-Binding Properties

Veronika Vetyskova, Monika Zouharova, Lucie Bednarova, Ondřej Vaněk, Petra Sázelová, …, Tatsiana Charnavets, Klara Postulkova, Janne E. Reseland, Kristyna Bousova, Jiri Vondrasek

International Journal of Molecular Sciences  ·  05 Dec 2020  ·  doi:10.3390/IJMS21239293

In Vitro Quantification of the Effects of IP6 and Other Small Polyanions on Immature HIV-1 Particle Assembly and Core Stability

Alžběta Dostálková, Filip Kaufman, Ivana Křížová, Barbora Vokatá, Tomáš Ruml, Michaela Rumlová

Journal of Virology  ·  29 Sep 2020  ·  doi:10.1128/jvi.00991-20

In Vitro Quantification of the Effects of IP6 and Other Small Polyanions on Immature HIV-1 Particle Assembly and Core Stability

Alžběta Dostálková, Filip Kaufman, Ivana Křížová, Barbora Vokatá, Tomáš Ruml, Michaela Rumlová

Journal of Virology  ·  29 Sep 2020  ·  doi:10.1128/JVI.00991-20

Octahedral Molybdenum Cluster Complexes with Optimized Properties for Photodynamic Applications

Kaplan Kirakci, Jaroslav Zelenka, Ivana Křížová, Tomáš Ruml, Kamil Lang

Inorganic Chemistry  ·  09 Jun 2020  ·  doi:10.1021/acs.inorgchem.0c01173

Characterization and in vitro assembly of tick‐borne encephalitis virus C protein

Filip Kaufman, Alžběta Dostálková, Lukáš Pekárek, Tung Dinh Thanh, Marina Kapisheva, …, Jiří Černý, Libor Grubhoffer, Tomáš Ruml, Richard Hrabal, Michaela Rumlová

FEBS Letters  ·  01 Jun 2020  ·  doi:10.1002/1873-3468.13857

PF74 and Its Novel Derivatives Stabilize Hexameric Lattice of HIV-1 Mature-Like Particles

Alžběta Dostálková, Kryštof Škach, Filip Kaufman, Ivana Křížová, Romana Hadravová, Martin Flegel, Tomáš Ruml, Richard Hrabal, Michaela Rumlová

Molecules  ·  20 Apr 2020  ·  doi:10.3390/molecules25081895

2019

PEGylated Purpurin 18 with Improved Solubility: Potent Compounds for Photodynamic Therapy of Cancer

Vladimíra Pavlíčková, Silvie Rimpelová, Michal Jurášek, Kamil Záruba, Jan Fähnrich, …, Jiří Bejček, Zdeňka Rottnerová, Vojtěch Spiwok, Pavel Drašar, Tomáš Ruml

Molecules  ·  06 Dec 2019  ·  doi:10.3390/molecules24244477

Phosphinate Apical Ligands: A Route to a Water-Stable Octahedral Molybdenum Cluster Complex

Kaplan Kirakci, Jan Demel, Jan Hynek, Jaroslav Zelenka, Michaela Rumlová, Tomáš Ruml, Kamil Lang

Inorganic Chemistry  ·  03 Dec 2019  ·  doi:10.1021/ACS.INORGCHEM.9B02569

A simple, high-throughput stabilization assay to test HIV-1 uncoating inhibitors

Alžběta Dostálková, Romana Hadravová, Filip Kaufman, Ivana Křížová, Kryštof Škach, Martin Flegel, Richard Hrabal, Tomáš Ruml, Michaela Rumlová

Scientific Reports  ·  19 Nov 2019  ·  doi:10.1038/s41598-019-53483-w

Cobalt bis-dicarbollide and its ammonium derivatives are effective antimicrobial and antibiofilm agents

Eva Vaňková, Kristýna Lokočová, Olga Maťátková, Ivana Křížová, Jan Masák, Bohumír Grüner, Pavel Kaule, Jan Čermák, Václav Šícha

Journal of Organometallic Chemistry  ·  01 Oct 2019  ·  doi:10.1016/j.jorganchem.2019.120891

Biocompatibility of Ar plasma-treated fluorinated ethylene propylene: Adhesion and viability of human keratinocytes

Lucie Peterková, Silvie Rimpelová, Ivana Křížová, Petr Slepička, Nikola Slepičková Kasálková, Václav Švorčík, Tomáš Ruml

Materials Science and Engineering: C  ·  01 Jul 2019  ·  doi:10.1016/j.msec.2019.02.100

Argon plasma-treated fluorinated ethylene propylene: Growth of primary dermal fibroblasts and mesenchymal stem cells

Lucie Peterková, Silvie Rimpelová, Petr Slepička, Ivana Křížová, Nikola Slepičková Kasálková, Václav Švorčík, Tomáš Ruml

Tissue and Cell  ·  01 Jun 2019  ·  doi:10.1016/j.tice.2019.05.004

Nuclear transport of nicotinamide phosphoribosyltransferase is cell cycle–dependent in mammalian cells, and its inhibition slows cell growth

Petr Svoboda, Edita Krizova, Sarka Sestakova, Kamila Vapenkova, Zdenek Knejzlik, …, Rene Kizek, Martin Haluzik, Vaclav Zidek, Jarmila Zidkova, Vojtech Skop

Journal of Biological Chemistry  ·  01 May 2019  ·  doi:10.1074/jbc.RA118.003505

Nuclear transport of nicotinamide phosphoribosyltransferase is cell cycle–dependent in mammalian cells, and its inhibition slows cell growth

Petr Svoboda, Edita Krizova, Sarka Sestakova, Kamila Vapenkova, Zdenek Knejzlik, …, Rene Kizek, Martin Haluzik, Vaclav Zidek, Jarmila Zidkova, Vojtech Skop

Journal of Biological Chemistry  ·  01 May 2019  ·  doi:10.1074/jbc.ra118.003505

Various AKIP1 Expression Levels Affect Its Subcellular Localization but Have no Effect on NF-κB Activation

A. KEPROVÁ, L. KOŘÍNKOVÁ, I. KŘÍŽOVÁ, R. HADRAVOVÁ, F. KAUFMAN, I. PICHOVÁ, T. RUML, M. RUMLOVÁ

Physiological Research  ·  22 Mar 2019  ·  doi:10.33549/physiolres.933961

Various AKIP1 Expression Levels Affect Its Subcellular Localization but Have no Effect on NF-κB Activation

A. KEPROVÁ, L. KOŘÍNKOVÁ, I. KŘÍŽOVÁ, R. HADRAVOVÁ, F. KAUFMAN, I. PICHOVÁ, T. RUML, M. RUMLOVÁ

Physiological Research  ·  22 Mar 2019  ·  doi:10.33549/PHYSIOLRES.933961

Cationic octahedral molybdenum cluster complexes functionalized with mitochondria-targeting ligands: photodynamic anticancer and antibacterial activities

Kaplan Kirakci, Jaroslav Zelenka, Michaela Rumlová, Josef Cvačka, Tomáš Ruml, Kamil Lang

Biomaterials Science  ·  01 Jan 2019  ·  doi:10.1039/C8BM01564C

2018

The nanoscaled metal-organic framework ICR-2 as a carrier of porphyrins for photodynamic therapy

Jan Hynek, Sebastian Jurík, Martina Koncošová, Jaroslav Zelenka, Ivana Křížová, …, Kaplan Kirakci, Ivo Jakubec, František Kovanda, Kamil Lang, Jan Demel

Beilstein Journal of Nanotechnology  ·  30 Nov 2018  ·  doi:10.3762/bjnano.9.275

Structure and architecture of immature and mature murine leukemia virus capsids

Kun Qu, Bärbel Glass, Michal Doležal, Florian K. M. Schur, Brice Murciano, Alan Rein, Michaela Rumlová, Tomáš Ruml, Hans-Georg Kräusslich, John A. G. Briggs

Proceedings of the National Academy of Sciences  ·  26 Nov 2018  ·  doi:10.1073/pnas.1811580115

Mason-Pfizer Monkey Virus Envelope Glycoprotein Cycling and Its Vesicular Co-Transport with Immature Particles

Petra Grznárová Prokšová, Jan Lipov, Jaroslav Zelenka, Eric Hunter, Hana Langerová, Michaela Rumlová, Tomáš Ruml

Viruses  ·  20 Oct 2018  ·  doi:10.3390/V10100575

Conserved cysteines in Mason–Pfizer monkey virus capsid protein are essential for infectious mature particle formation

Růžena Píchalová, Tibor Füzik, Barbora Vokatá, Michaela Rumlová, Manuel Llano, Alžběta Dostálková, Ivana Křížová, Tomáš Ruml, Pavel Ulbrich

Virology  ·  01 Aug 2018  ·  doi:10.1016/j.virol.2018.06.001

Conserved cysteines in Mason–Pfizer monkey virus capsid protein are essential for infectious mature particle formation

Růžena Píchalová, Tibor Füzik, Barbora Vokatá, Michaela Rumlová, Manuel Llano, Alžběta Dostálková, Ivana Křížová, Tomáš Ruml, Pavel Ulbrich

Virology  ·  01 Aug 2018  ·  doi:10.1016/J.VIROL.2018.06.001

Heart Rate Variability During Long-Term Air Traffic Control in Cadets

Petr Volf, Patrik Kutilek, Jan Hejda, Pavel Smrcka, Vaclav Krivanek, Radek Doskocil, Jan Farlik, Josef Casar, Michaela Klikova

2018 41st International Conference on Telecommunications and Signal Processing (TSP)  ·  01 Jul 2018  ·  doi:10.1109/TSP.2018.8441257

Mutations in the Basic Region of the Mason-Pfizer Monkey Virus Nucleocapsid Protein Affect Reverse Transcription, Genomic RNA Packaging, and the Virus Assembly Site

Alžběta Dostálková, Filip Kaufman, Ivana Křížová, Anna Kultová, Karolína Strohalmová, Romana Hadravová, Tomáš Ruml, Michaela Rumlová

Journal of Virology  ·  15 May 2018  ·  doi:10.1128/JVI.00106-18

Mutations in the Basic Region of the Mason-Pfizer Monkey Virus Nucleocapsid Protein Affect Reverse Transcription, Genomic RNA Packaging, and the Virus Assembly Site

Alžběta Dostálková, Filip Kaufman, Ivana Křížová, Anna Kultová, Karolína Strohalmová, Romana Hadravová, Tomáš Ruml, Michaela Rumlová

Journal of Virology  ·  15 May 2018  ·  doi:10.1128/jvi.00106-18

In vitro methods for testing antiviral drugs

Michaela Rumlová, Tomáš Ruml

Biotechnology Advances  ·  01 May 2018  ·  doi:10.1016/j.biotechadv.2017.12.016

Does BCA3 Play a Role in the HIV-1 Replication Cycle?

Michaela Rumlová, Ivana Křížová, Jaroslav Zelenka, Jan Weber, Tomáš Ruml

Viruses  ·  20 Apr 2018  ·  doi:10.3390/v10040212

Phosphinatophenylporphyrins tailored for high photodynamic efficacy

Jan Hynek, Martina Koncošová, Jaroslav Zelenka, Ivana Křížová, Tomáš Ruml, Pavel Kubát, Jan Demel, Kamil Lang

Organic & Biomolecular Chemistry  ·  01 Jan 2018  ·  doi:10.1039/c8ob01984c

Octahedral molybdenum clusters as radiosensitizers for X-ray induced photodynamic therapy

Kaplan Kirakci, Jaroslav Zelenka, Michaela Rumlová, Jiří Martinčík, Martin Nikl, Tomáš Ruml, Kamil Lang

Journal of Materials Chemistry B  ·  01 Jan 2018  ·  doi:10.1039/C8TB00893K

2017

Thermal Carbon Analysis Enabling Comprehensive Characterization of Lignin and Its Degradation Products

Keith Voeller, Honza Bílek, Jasmine Kreft, Alžběta Dostálková, Evguenii Kozliak, Alena Kubátová

ACS Sustainable Chemistry & Engineering  ·  19 Oct 2017  ·  doi:10.1021/acssuschemeng.7b02392

Optimized method for isolation of immature intracytoplasmic retroviral particles from mammalian cells

Hana Langerová, Tomáš Ruml, Michaela Rumlová

Journal of Virological Methods  ·  01 Oct 2017  ·  doi:10.1016/J.JVIROMET.2017.06.003

Conjugation of chlorins with spermine enhances phototoxicity to cancer cells in vitro

Mariia Darmostuk, Michal Jurášek, Kamila Lengyel, Jaroslav Zelenka, Michaela Rumlová, Pavel Drašar, Tomáš Ruml

Journal of Photochemistry and Photobiology B: Biology  ·  01 Mar 2017  ·  doi:10.1016/J.JPHOTOBIOL.2017.02.012

Nanoscaled porphyrinic metal–organic frameworks: photosensitizer delivery systems for photodynamic therapy

Daniel Bůžek, Jaroslav Zelenka, Pavel Ulbrich, Tomáš Ruml, Ivana Křížová, Jan Lang, Pavel Kubát, Jan Demel, Kaplan Kirakci, Kamil Lang

Journal of Materials Chemistry B  ·  01 Jan 2017  ·  doi:10.1039/c6tb03230c

2016

Membrane Interactions of the Mason-Pfizer Monkey Virus Matrix Protein and Its Budding Deficient Mutants

Tomáš Kroupa, Hana Langerová, Michal Doležal, Jan Prchal, Vojtěch Spiwok, Eric Hunter, Michaela Rumlová, Richard Hrabal, Tomáš Ruml

Journal of Molecular Biology  ·  01 Nov 2016  ·  doi:10.1016/J.JMB.2016.10.010

Functional and Structural Characterization of Novel Type of Linker Connecting Capsid and Nucleocapsid Protein Domains in Murine Leukemia Virus

Michal Doležal, Romana Hadravová, Milan Kožíšek, Lucie Bednárová, Hana Langerová, Tomáš Ruml, Michaela Rumlová

Journal of Biological Chemistry  ·  01 Sep 2016  ·  doi:10.1074/JBC.M116.746461

Nucleic Acid Binding by Mason-Pfizer Monkey Virus CA Promotes Virus Assembly and Genome Packaging

Tibor Füzik, Růžena Píchalová, Florian K. M. Schur, Karolína Strohalmová, Ivana Křížová, Romana Hadravová, Michaela Rumlová, John A. G. Briggs, Pavel Ulbrich, Tomáš Ruml

Journal of Virology  ·  01 May 2016  ·  doi:10.1128/JVI.03197-15

2015

FAITH – Fast Assembly Inhibitor Test for HIV

Romana Hadravová, Michaela Rumlová, Tomáš Ruml

Virology  ·  01 Dec 2015  ·  doi:10.1016/j.virol.2015.08.029

Resonance assignments of the myristoylated Y28F/Y67F mutant of the Mason-Pfizer monkey virus matrix protein

Michal Doležal, Richard Hrabal, Tomáš Ruml, Michaela Rumlová

Biomolecular NMR Assignments  ·  15 Mar 2015  ·  doi:10.1007/S12104-014-9580-0

2014

Role of Mason-Pfizer Monkey Virus CA-NC Spacer Peptide-Like Domain in Assembly of Immature Particles

Karolína Strohalmová-Bohmová, Vojtěch Spiwok, Martin Lepšík, Romana Hadravová, Ivana Křížová, Pavel Ulbrich, Iva Pichová, Lucie Bednárová, Tomáš Ruml, Michaela Rumlová

Journal of Virology  ·  15 Dec 2014  ·  doi:10.1128/JVI.02286-14

Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolution

Florian K. M. Schur, Wim J. H. Hagen, Michaela Rumlová, Tomáš Ruml, Barbara Müller, Hans-Georg Kräusslich, John A. G. Briggs

Nature  ·  02 Nov 2014  ·  doi:10.1038/nature13838

Stabilization of the β-hairpin in Mason-Pfizer monkey virus capsid protein- a critical step for infectivity

Martin Obr, Romana Hadravová, Michal Doležal, Ivana Křžová, Veronika Papoušková, Lukáš Žídek, Richard Hrabal, Tomáš Ruml, Michaela Rumlová

Retrovirology  ·  30 Oct 2014  ·  doi:10.1186/S12977-014-0094-8

Breast cancer-associated protein – a novel binding partner of Mason-Pfizer monkey virus protease

Michaela Rumlová, Ivana Křížová, Romana Hadravová, Michal Doležal, Karolína Strohalmová, Alena Keprová, Iva Pichová, Tomáš Ruml

Journal of General Virology  ·  01 Jun 2014  ·  doi:10.1099/VIR.0.064345-0

HIV-1 protease-induced apoptosis

Michaela Rumlová, Ivana Křížová, Alena Keprová, Romana Hadravová, Michal Doležal, Karolína Strohalmová, Iva Pichová, Miroslav Hájek, Tomáš Ruml

Retrovirology  ·  20 May 2014  ·  doi:10.1186/1742-4690-11-37

2013

One-step separation of myristoylated and nonmyristoylated retroviral matrix proteins

Michal Doležal, Aleš Zábranský, Richard Hrabal, Tomáš Ruml, Iva Pichová, Michaela Rumlová

Protein Expression and Purification  ·  01 Nov 2013  ·  doi:10.1016/J.PEP.2013.09.003

2012

β‐Cyclodextrin Duplexes That Are Connected through Two Disulfide Bonds: Potent Hosts for the Complexation of Organic Molecules

Anastasia Grishina, Stancho Stanchev, Lukáš Kumprecht, Miloš Buděšínský, Michaela Pojarová, Michal Dušek, Michaela Rumlová, Ivana Křížová, Lubomír Rulíšek, Tomáš Kraus

Chemistry – A European Journal  ·  22 Aug 2012  ·  doi:10.1002/CHEM.201201239

Structure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopy

Tanmay A. M. Bharat, Norman E. Davey, Pavel Ulbrich, James D. Riches, Alex de Marco, Michaela Rumlova, Carsten Sachse, Tomas Ruml, John A. G. Briggs

Nature  ·  03 Jun 2012  ·  doi:10.1038/nature11169

The G-Patch Domain of Mason-Pfizer Monkey Virus Is a Part of Reverse Transcriptase

Ivana Křížová, Romana Hadravová, Jitka Štokrová, Jana Günterová, Michal Doležal, Tomáš Ruml, Michaela Rumlová, Iva Pichová

Journal of Virology  ·  15 Feb 2012  ·  doi:10.1128/JVI.06638-11

In Vitro Assembly of Virus-Like Particles of a Gammaretrovirus, the Murine Leukemia Virus XMRV

Romana Hadravová, Alex de Marco, Pavel Ulbrich, Jitka Štokrová, Michal Doležal, Iva Pichová, Tomáš Ruml, John A. G. Briggs, Michaela Rumlová

Journal of Virology  ·  01 Feb 2012  ·  doi:10.1128/jvi.05564-11

2011

Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG

Helena Mertlíková-Kaiserová, Michaela Rumlová, Eva Tloušťová, Eliška Procházková, Antonín Holý, Ivan Votruba

Biochemical Pharmacology  ·  01 Jul 2011  ·  doi:10.1016/J.BCP.2011.04.002

2010

P.3.f.003 Effect of clozapine on behavioural and cytokine profiles in rats with lipopolysaccharide and viral protein stimulation

H. Tejkalová, T. Ruml, M. Rumlová, J. Klaschka, S. Ruzicková

European Neuropsychopharmacology  ·  01 Aug 2010  ·  doi:10.1016/S0924-977X(10)70768-9

Effect of Dimerizing Domains and Basic Residues on In Vitro and In Vivo Assembly of Mason-Pfizer Monkey Virus and Human Immunodeficiency Virus

Karolína Bohmová, Romana Hadravová, Jitka Štokrová, Roman Tůma, Tomáš Ruml, Iva Pichová, Michaela Rumlová

Journal of Virology  ·  15 Feb 2010  ·  doi:10.1128/JVI.02022-09

2009

NMR Structure of the N-Terminal Domain of Capsid Protein from the Mason–Pfizer Monkey Virus

Pavel Macek, Josef Chmelík, Ivana Křížová, Pavel Kadeřávek, Petr Padrta, …, Radka Chaloupková, Iva Pichová, Tomáš Ruml, Michaela Rumlová, Vladimír Sklenář

Journal of Molecular Biology  ·  01 Sep 2009  ·  doi:10.1016/J.JMB.2009.06.029

The impact of altered polyprotein ratios on the assembly and infectivity of Mason-Pfizer monkey virus

Zdena Kohoutová, Michaela Rumlová, Martin Andreánsky, Michael Sakalian, Eric Hunter, Iva Pichová, Tomáš Ruml

Virology  ·  01 Feb 2009  ·  doi:10.1016/J.VIROL.2008.10.048

2008

The effect of point mutations within the N-terminal domain of Mason-Pfizer monkey virus capsid protein on virus core assembly and infectivity

Marcela Wildová, Romana Hadravová, Jitka Štokrová, Ivana Křížová, Tomáš Ruml, Eric Hunter, Iva Pichová, Michaela Rumlová

Virology  ·  01 Oct 2008  ·  doi:10.1016/J.VIROL.2008.07.021

P.3.f.006 Neonatal administration of HIV-1 proteins alters behaviour and NMDA receptor binding in the adult rat brain

H.B. Tejkalová, T. Ruml, M. Rumlová, J. Klaschka, J. Myslivecek, F. Stastny

European Neuropsychopharmacology  ·  01 Aug 2008  ·  doi:10.1016/S0924-977X(08)70711-9

D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein

Jiří Vlach, Jan Lipov, Michaela Rumlová, Václav Veverka, Jan Lang, …, Zdeněk Knejzlík, Iva Pichová, Eric Hunter, Richard Hrabal, Tomáš Ruml

Proceedings of the National Academy of Sciences  ·  29 Jul 2008  ·  doi:10.1073/PNAS.0801765105

1H, 13C, and 15N resonance assignment of the N-terminal domain of Mason-Pfizer monkey virus capsid protein, CA 1-140

Pavel Macek, Lukáš Žídek, Michaela Rumlová, Iva Pichová, Vladimír Sklenář

Biomolecular NMR Assignments  ·  26 Mar 2008  ·  doi:10.1007/S12104-008-9080-1

2006

Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins

V. Nemeth-Pongracz, O. Barabas, M. Fuxreiter, I. Simon, I. Pichova, …, E. Klement, E. Hunyadi-Gulyas, K. F. Medzihradszky, E. Konya, B. G. Vertessy

Nucleic Acids Research  ·  14 Dec 2006  ·  doi:10.1093/NAR/GKL1074

Distinct Roles for Nucleic Acid in In Vitro Assembly of Purified Mason-Pfizer Monkey Virus CANC Proteins

Pavel Ulbrich, Sarka Haubova, Milan V. Nermut, Eric Hunter, Michaela Rumlova, Tomas Ruml

Journal of Virology  ·  15 Jul 2006  ·  doi:10.1128/JVI.02694-05

Interacting Partners of M-PMV Nucleocapsid-DUTPase

V. Németh-Pongrácz, J. Snasel, M. Rumlova, I. Pichova, B. G. Vértessy

Nucleosides, Nucleotides and Nucleic Acids  ·  01 Jun 2006  ·  doi:10.1080/15257770600894535

2005

Luminometric method for screening retroviral protease inhibitors

Dana Horáková, Michaela Rumlová, Iva Pichová, Tomáš Ruml

Analytical Biochemistry  ·  01 Oct 2005  ·  doi:10.1016/J.AB.2005.07.013

Letter to the Editor: Assignment of 1H, 13C, and 15N resonances of WT matrix protein and its R55F mutant from Mason-Pfizer monkey virus

J. Vlach, J. Lipov, V. Veverka, M. Rumlová, T. Ruml, R. Hrabal

Journal of Biomolecular NMR  ·  01 Apr 2005  ·  doi:10.1007/S10858-005-2473-X

2003

dUTPase and Nucleocapsid Polypeptides of the Mason-Pfizer Monkey Virus Form a Fusion Protein in the Virion with Homotrimeric Organization and Low Catalytic Efficiency

Orsolya Barabás, Michaela Rumlová, Anna Erdei, Veronika Pongrácz, Iva Pichová, Beáta G. Vértessy

Journal of Biological Chemistry  ·  01 Oct 2003  ·  doi:10.1074/JBC.M306967200

Specific in vitro cleavage of Mason–Pfizer monkey virus capsid protein: evidence for a potential role of retroviral protease in early stages of infection

Michaela Rumlová, Tomáš Ruml, Jan Pohl, Iva Pichová

Virology  ·  01 Jun 2003  ·  doi:10.1016/S0042-6822(03)00128-4

2002

Molecular Organization of Mason-Pfizer Monkey Virus Capsids Assembled from Gag Polyprotein in Escherichia coli

Milan V. Nermut, Patrick Bron, Daniel Thomas, Michaela Rumlova, Tomas Ruml, Eric Hunter

Journal of Virology  ·  01 May 2002  ·  doi:10.1128/JVI.76.9.4321-4330.2002

2001

Structural Aspects of Retrovirus Assembly

Virus Research  ·  01 Oct 2001  ·  doi:10.1016/S0168-1702(01)00309-4

Comparison of Classical and Affinity Purification Techniques of Mason-Pfizer Monkey Virus Capsid Protein: The Alteration of the Product by an Affinity Tag

Michaela Rumlová, Jitka Benedı́ková, Romana Cubı́nková, Iva Pichová, Tomás̆ Ruml

Protein Expression and Purification  ·  01 Oct 2001  ·  doi:10.1006/PREP.2001.1488

Autoprocessing of Mason-Pfizer Monkey Virus Protease

Virus Research  ·  01 Oct 2001  ·  doi:10.1016/S0168-1702(01)00326-4

2000

Analysis of Mason-Pfizer Monkey Virus Gag Domains Required for Capsid Assembly in Bacteria: Role of the N-Terminal Proline Residue of CA in Directing Particle Shape

Michaela Rumlova-Klikova, Eric Hunter, Milan V. Nermut, Iva Pichova, Tomas Ruml

Journal of Virology  ·  15 Sep 2000  ·  doi:10.1128/JVI.74.18.8452-8459.2000

1999

Conditions Resulting in Formation of Properly Assembled Retroviral Capsids within Inclusion Bodies of Escherichia coli

Michaela Rumlová-Kliková, Iva Pichová, Eric Hunter, Tomáš Ruml

Collection of Czechoslovak Chemical Communications  ·  01 Jan 1999  ·  doi:10.1135/CCCC19991348

1997

The three‐dimensional solution structure of the matrix protein from the type D retrovirus, the Mason–Pfizer monkey virus, and implications for the morphology of retroviral assembly

Maria R. Conte, Michaela Klikova, Eric Hunter, Tomas Ruml, Stephen Matthews

The EMBO Journal  ·  01 Oct 1997  ·  doi:10.1093/EMBOJ/16.19.5819

1995

Efficient in vivo and in vitro assembly of retroviral capsids from Gag precursor proteins expressed in bacteria

M Klikova, S S Rhee, E Hunter, T Ruml

Journal of Virology  ·  01 Feb 1995  ·  doi:10.1128/JVI.69.2.1093-1098.1995